RETRACING LOSS OF MOMENTUM FOR PRIMARY HEALTH CARE: CAN RENEWED POLITICAL INTEREST IN THE CONTEXT OF COVID-19 BE A TURNING POINT?

Retracing loss of momentum for primary health care: can renewed political interest in the context of COVID-19 be a turning point?

The COVID-19 pandemic has revealed major weaknesses in primary health care (PHC), and how such weaknesses pose a catastrophic threat to humanity.As a result, strengthening PHC has re-emerged as a global health priority and will take centre stage at the 2023 United Nations High Level Meeting (UNHLM) on Universal Health Coverage (UHC).In this analysi

read more

Aggregated clumps of lithistid sponges: a singular, reef-like bathyal habitat with relevant paleontological connections.

The advent of deep-sea exploration using video cameras has uncovered extensive sponge aggregations in virtually all oceans.Yet, a distinct type is herein reported from the Mediterranean: a monospecific reef-like formation built by the lithistid demosponge Leiodermatium pfeifferae.Erect, plate-like individuals (up to 80 cm) form bulky clumps, making

read more

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.

Lung adenocarcinomas from patients who respond to the tyrosine kinase inhibitors gefitinib (Iressa) or erlotinib (Tarceva) usually harbor somatic gain-of-function mutations in exons encoding the kinase domain of the epidermal growth factor receptor (EGFR).Despite initial responses, patients eventually progress by unknown mechanisms of "acquired" re

read more